Published 2007 | Version v1
Report Open

Participation of SRM5/CDC28, SRM8/NET1 and SRM12/HF11 genes in activation of checkpoints of Yeast Saccharomyces Cerevisiae

Creators

Description

It is known that there are about twenty checkpoint genes in yeast Saccharomyces cerevisiae. We study participation of SRM genes selected as genes affecting genetic stability and radiosensitivity. It has been shown that srm5/cdc28-srm, srm8/net1-srm, srm12/hfil-srm mutations prevent checkpoint activation by DNA damage, particularly G0/S-checkpoint (srm5, srm8), G1/S-checkpoint (srm5, srm8, srm12), S-checkpoint (srm5, srm12) and G2-checkpoint (srm5). These data indicate, at least in budding yeast, CDC28/SRM5, HF11/ADA1/SRM12 and NET1/SRM8 genes mediate cellular response induced by DNA damage including checkpoint control

Availability note (English)

Available from INIS in electronic form; Also available online: http://www1.jinr.ru/Preprints/Preprints_index.html

Files

40094989.pdf

Files (2.5 MB)

Name Size Download all
md5:3fc0f7c8e59680b6e7b391d64fdd642f
2.5 MB Preview Download

Additional details

Additional titles

Original title (Russian)
Uchastie genov SRM5/CDC28, SRM8/NET1, SRM12/HF11 v aktivatsii chekpojnt-kontrolya u drozhzhej Saccharomyces cerevisiae

Identifiers

URL
http://www1.jinr.ru/Preprints/Preprints_index.html;

Publishing Information

Imprint Pagination
36 p.
Report number
JINR-R--19-2007-168

INIS

Country of Publication
Joint Institute for Nuclear Research (JINR)
Country of Input or Organization
Joint Institute for Nuclear Research (JINR)
INIS RN
40094989
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CELL CYCLE; DNA DAMAGES; DNA REPLICATION; GENE MUTATIONS; HYDROXYUREA; IRRADIATION; MUTATION FREQUENCY; RADIOSENSITIVITY; SPONTANEOUS MUTATIONS; SURVIVAL CURVES; ULTRAVIOLET RADIATION; YEASTS
Descriptors DEC
AMIDES; ELECTROMAGNETIC RADIATION; EUMYCOTA; FUNGI; HYDROXY COMPOUNDS; MICROORGANISMS; MUTATIONS; NUCLEIC ACID REPLICATION; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PLANTS; RADIATIONS; SENSITIVITY

Optional Information

Notes
90 refs., 6 figs., 5 tabs. Submitted to the journal, Genetika