Percutaneous biliary stenting combined with intraluminal implantation of ¹²⁵I seed strand for malignant obstructive jaundice:analysis of curative effect

Objective: To evaluate the safety, efficacy and clinical application value of percutaneous transhepatic biliary stenting with ¹²⁵I seed strand implantation in the treatment of malignant obstructive jaundice (MOJ). Methods: The clinical data of 142 patients with MOJ, who were admitted to authors' department during the period from November 2015 to February 2018 to receive treatment, were retrospectively analyzed. Of the 142 patients, bare stent combined with ¹²⁵I seed strand implantation was performed in 50 (study group) and simple bare stent implantation was adopted in 92 (control group). The stent patency, survival time and postoperative complications of the two groups were recorded. Results: In the study group the median time of stent patency was 226 days and the median survival time was 194 days, which in the control group were 86 days and 117 days respectively, the results in the study group were significantly better than those in the control group (P < 0.05). In the study group, seed strand containing 8-22 ¹²⁵I seeds(average of 15 ¹²⁵I seeds) and bare stent were simultaneously implanted into the biliary duct. One week after treatment, the liver function examination showed that the levels of total bilirubin, direct bilirubin and alanine aminotransferase were remarkably decreased when compared with the preoperative ones, but no statistically significant differences in the changes of liver function existed between the two groups (P > 0.05). Severe complication occurred only in one patient of the control group. Conclusion: For the treatment of MOJ, the combination use of bare stent and ¹²⁵I seed strand is effective and safe. It can improve stent patency time and patient survival time. Therefore, this therapy is worthy of further clinical study. (authors)