Published 1979
| Version v1
Journal article
Accumulation of radioiodinated tyrosine derivatives in the adrenal medulla and in melanomas
Description
Because tyrosine and dopa can be regarded as precursors of adrenomedullary hormones and melanin, radioiodinated derivatives of these compound were tested for their accumulation in the adrenal medulla and in melanomas of various animal species. The highest level of accumulation in the adrenal medullar was attained in mice and rats with iodinated β-hydroxy-α-methyltyramine, and in melanomas of mice with iodinated α-methyltyrosine. The results could not be reproduced to the same extent in other species. (orig.)
Abstract (German)
Da Tyrosin und Dopa als Vorstufen von Hormonen des Nebennierenmarks und Melanin angesehen werden koennen, wurden mit Radiojod markierte Derivate dieser Verbindungen auf ihre Akkumulation im Nebennierenmark und in Melanomen in verschiedenen Tierarten untersucht. Die hoechsten Werte fuer die Akkumulation im Nebennierenmark wurden bei Maeusen und Ratten nach Verwendung von jodgebundenem β-Hydroxy-α-Methyltyramin gefunden, bei den Melanomen ergab sich ein Hoechstwert in Maeusen mit jodgebundenem α-Methyltyrosin. Bei anderen Tierarten wurden diese Werte nicht erreicht. (orig.)Additional details
Publishing Information
- Journal Title
- Eur. J. Nucl. Med.
- Journal Volume
- 4
- Journal Issue
- 3
- Series
- Eur. J. Nucl. Med.
- Journal Page Range
- 179-186
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 10487704
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ADRENAL GLANDS; CATS; DOGS; DOPA; HAMSTERS; HORMONES; IODINE 131; LABELLED COMPOUNDS; MEDICINE; MELAMINE; MELANOMAS; MICE; PRECURSOR; RABBITS; RATS; SYNTHESIS; TRACER TECHNIQUES; TYROSINE; UPTAKE
- Descriptors DEC
- AMINES; AMINO ACIDS; ANIMALS; AROMATICS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; DAYS LIVING RADIOISOTOPES; DISEASES; ENDOCRINE GLANDS; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROXY ACIDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIOISOTOPES; RODENTS; TRIAZINES; VERTEBRATES