Published 1986
| Version v1
Journal article
Influence of chloramine T iodination on the biological and immunological activity or the molecular radius of the human growth hormone molecule
Description
Potential alterations of the somatotropic activity of human growth hormone (hGH) resulting from Chloramine T labelling reaction, iodination up to 2.7 atoms/molecule and indirect radiation effects, have been studied. Three 2X2 factorial assays, performed in hypophysectomized rats, failed to reveal any significant difference (P greater than 0.05) in true growth promoting activity between hGH and (127-I)hGH, even after storing the latter with 125-I. Similar results were obtained applying a sensitive and precise gel filtration technique for Stokes Radius determination and radioimmunoassay
Additional details
Publishing Information
- Journal Title
- J. Immunoassay
- Journal Issue
- no.3
- Series
- J. Immunoassay.
- ISSN
- 0197-1522
- CODEN
- JOUID
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18018187
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL FUNCTIONS; CHEMICAL RADIATION EFFECTS; CHLORAMINES; IODINE 125; LABELLED COMPOUNDS; RADIOIMMUNOASSAY; RATS; STH
- Descriptors DEC
- AMINES; ANIMALS; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; HORMONES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; PEPTIDE HORMONES; PITUITARY HORMONES; RADIATION EFFECTS; RADIOISOTOPES; RODENTS; TRACER TECHNIQUES; VERTEBRATES