Clinical significance of determination of changes of serum hs-CRP, TNF-α and E2 levels in female children with simple obesity

Objective: To explore the clinical significance of changes of serum hs-CRP, TNF-α and E2 levels in female children with simple obesity. Methods: Serum levels of TNF-α, E2 (with RIA) and hs-CRP (with immunity turbidity) were detected in 34 female children with simple obesity and 35 controls. Results: In the children with simple obesity, the serum hs-CRP, TNF- α and E2 levels were significantly higher than those in controls (P<0.01). E2 levels were mutually positively correlated (r=0.6182, 0.5784, P<0.01) with those of hs-CRP and TNF-α. Conclusion: Determination of serum hs-CRP, TNF-α and E2 levels is of help for assessment of severity of obesity as well as outcome prediction in female children. (authors)