Published January 1982 | Version v1
Miscellaneous Metadata-only

The influence of sex steroids on pineal enzymes

Creators

Description

The influence of the gonadal sex steroids namely, estradiol, progesterone and testosterone on the two major enzymes responsible for the synthesis of melatonin in the pineal gland was investigated. These enzymes are Serotonin-N-acetyltransferase (SNAT) and Hydroxyindole-O-methyltransferase (H10MT). Testosterone was found to be the only sex steroid capable of influencing SNAT activity whereas all three of the sex steroids were found to influence H10MT activity in a biphasic dose-dependent manner. The influence of these sex steroids on radiolabelled serotonin metabolism by pineals in organ culture was also investigated. Ovariectomy, castration and the sex steroids were all found to alter the pattern of the radiolabelled serotonin metabolism by these pineal glands in organ culture

Availability note (English)

Available from the Registrar, Rhodes University, P.O. Box 94, Grahamstown, 6140, South Africa.

Additional details

Publishing Information

Imprint Pagination
204 p.

INIS

Country of Publication
South Africa
Country of Input or Organization
South Africa
INIS RN
17072949
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Numerical Data, Thesis, Non-conventional Literature
Descriptors DEI
ALDOSTERONE; ANATOMY; ANIMAL CELLS; BIOCHEMISTRY; BRAIN; CARBON 14; CASTRATION; ENDOCRINE GLANDS; ENZYME ACTIVITY; ENZYMES; ESTRADIOL; ESTROUS CYCLE; EXPERIMENTAL DATA; GLUCOCORTICOIDS; GONADOTROPINS; LABELLED COMPOUNDS; LABELLING; MELATONIN; METABOLISM; OVARIES; PINEAL GLAND; PROGESTERONE; RADIOACTIVITY; RATS; RHYTHMICITY; SEROTONIN; SEX; TAURINE; TESTOSTERONE; TISSUE CULTURES; TRITIUM
Descriptors DEC
ADRENAL HORMONES; ALDEHYDES; AMINES; ANDROGENS; ANDROSTANES; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENT; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGY; BODY; CARBON ISOTOPES; CENTRAL NERVOUS SYSTEM; CHEMISTRY; CORTICOSTEROIDS; DATA; DRUGS; ESTRANES; ESTROGENS; EVEN-EVEN NUCLEI; FEMALE GENITALS; GLANDS; GONADS; HETEROCYCLIC COMPOUNDS; HORMONES; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; INDOLES; INFORMATION; ISOTOPES; KETONES; LIGHT NUCLEI; MAMMALS; MEDICINE; MINERALOCORTICOIDS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PEPTIDE HORMONES; PITUITARY HORMONES; PREGNANES; PYRROLES; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; STEROID HORMONES; STEROIDS; SULFONIC ACIDS; SURGERY; SYMPATHOMIMETICS; TRYPTAMINES; VERTEBRATES; YEARS LIVING RADIOISOTOPES