Published 2017 | Version v1
Journal article Metadata-only

Radiation-induced damage in DNA

Creators

  • 1. Osaka University, Institute of Scientific and Industrial Research, Ibaraki, Osaka (Japan)

Description

Among the pathways of radiation-induced damage to DNA, the formation of H2O·+ and an electron by direct energy deposition in the hydration layer of DNA plays a crucial role in the initial stage. The formation of neutral sugar-phosphate radicals originating from the deoxyribose-phosphate backbone contributes a large fraction of strand breakage. In addition, the interaction of low-energy electrons with the DNA molecule, and the formation of clustered DNA damage are discussed here. (author)

Availability note (English)

Available from DOI: https://doi.org/10.3769/radioisotopes.66.479

Abstract (Japanese)

放射線照射によるDNA損傷の中でもDNAに溶媒和している水分子のイオン化により生成するH2O・+とDNAの反応過程が重要である。その中でも,糖-リン酸部位のラジカルの生成がDNA主鎖の切断を引き起こす。放射線化学反応の特徴である低エネルギー電子とDNAの反応や,修復することができない複数個の損傷が局在化して生成するclustered damageについて紹介する。(著者)

Additional details

Additional titles

Original title (Japanese)
放射線誘起反応によるDNA損傷

Identifiers

DOI
10.3769/radioisotopes.66.479;

Publishing Information

Journal Title
Radioisotopes (Online)
Journal Volume
66
Journal Issue
10
Journal Page Range
p. 479-487
ISSN
1884-4111

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
52100599
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
DNA; ELECTRON SPIN RESONANCE; ENZYMES; HYDROXYL RADICALS; IONIZATION; IRRADIATION; MUTATIONS; RADIATION CHEMISTRY; RADIATION INJURIES; REACTION INTERMEDIATES; STRAND BREAKS
Descriptors DEC
BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CHEMISTRY; DISEASES; DNA DAMAGES; INJURIES; MAGNETIC RESONANCE; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PROTEINS; RADIATION EFFECTS; RADICALS; RESONANCE

Optional Information

Notes
53 refs., 12 figs.