Published July 1991 | Version v1
Journal article Metadata-only

Effects of gastrointestinal hormonal peptides on the transformation of human peripheral lymphocytes

Creators

  • 1. Department of Veterans Affairs Medical Center, Jackson, MS (United States)

Description

The gastrointestinal peptides secretin and cholecystokinin were found to inhibit the incorporation of 3H-thymidine in the lymphocyte transformation reaction in response to phytohemagglutinin. Both peptides inhibited lymphocyte activation in a dose responsive fashion. This inhibition was not due to the toxicity of these substances, as the lymphocytes remained intact and capable of excluding trypan blue. Neither glucagon nor gastrin had any effects of lymphocyte transformation

Additional details

Publishing Information

Journal Title
Research Communications in Chemical Pathology and Pharmacology
Journal Volume
73
Journal Issue
1
Series
Res. Commun. Chem. Pathol. Pharmacol.
Journal Page Range
123-126
ISSN
0034-5164
CODEN
RCOCB

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
23022077
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
BIOCHEMICAL REACTION KINETICS; CELL TRANSFORMATIONS; DOSE-RESPONSE RELATIONSHIPS; GASTROINTESTINAL TRACT; IN VITRO; INHIBITION; KININS; LYMPHOCYTES; PEPTIDES; PHYTOHEMAGGLUTININ; SECRETIN; THYMIDINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS
Descriptors DEC
AGGLUTININS; ANIMAL CELLS; AZINES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOHYDRATES; CONNECTIVE TISSUE CELLS; DIGESTIVE SYSTEM; HEMAGGLUTININS; HETEROCYCLIC COMPOUNDS; HORMONES; HYDROGEN COMPOUNDS; ISOTOPE APPLICATIONS; KINETICS; LEUKOCYTES; MATERIALS; MITOGENS; MUCOPROTEINS; NUCLEOSIDES; NUCLEOTIDES; ONCOGENIC TRANSFORMATIONS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; POLYPEPTIDES; POLYSACCHARIDES; PROTEINS; PYRIMIDINES; REACTION KINETICS; RIBOSIDES; SACCHARIDES; SOMATIC CELLS