Published August 2015 | Version v1
Journal article Metadata-only

Quantifying [18F]fluorodeoxyglucose uptake in the arterial wall: the effects of dual time-point imaging and partial volume effect correction

Creators

  • 1. Odense University Hospital, Department of Nuclear Medicine, Odense (Denmark)
  • 2. University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands)
  • 3. Hospital of the University of Pennsylvania, Department of Radiology, Philadelphia, PA (United States)
  • 4. University of Groningen, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen (Netherlands)
  • 5. Geneva University Hospital, Division of Nuclear Medicine and Molecular Imaging, Geneva (Switzerland)

Description

The human arterial wall is smaller than the spatial resolution of current positron emission tomographs. Therefore, partial volume effects should be considered when quantifying arterial wall 18F-FDG uptake. We evaluated the impact of a novel method for partial volume effect (PVE) correction with contrast-enhanced CT (CECT) assistance on quantification of arterial wall 18F-FDG uptake at different imaging time-points. Ten subjects were assessed by CECT imaging and dual time-point PET/CT imaging at approximately 60 and 180 min after 18F-FDG administration. For both time-points, uptake of 18F-FDG was determined in the aortic wall by calculating the blood pool-corrected maximum standardized uptake value (cSUVMAX) and cSUVMEAN. The PVE-corrected SUVMEAN (pvcSUVMEAN) was also calculated using 18F-FDG PET/CT and CECT images. Finally, corresponding target-to-background ratios (TBR) were calculated. At 60 min, pvcSUVMEAN was on average 3.1 times greater than cSUVMAX (P <.0001) and 8.5 times greater than cSUVMEAN (P <.0001). At 180 min, pvcSUVMEAN was on average 2.6 times greater than cSUVMAX (P <.0001) and 6.6 times greater than cSUVMEAN (P <.0001). This study demonstrated that CECT-assisted PVE correction significantly influences quantification of arterial wall 18F-FDG uptake. Therefore, partial volume effects should be considered when quantifying arterial wall 18F-FDG uptake with PET. (orig.)

Availability note (English)

Available from: http://dx.doi.org/10.1007/s00259-015-3074-x

Additional details

Identifiers

DOI
10.1007/s00259-015-3074-x;

Publishing Information

Journal Title
European Journal of Nuclear Medicine and Molecular Imaging
Journal Volume
42
Journal Issue
9
Journal Page Range
p. 1414-1422
ISSN
1619-7070

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
46116942
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
AORTA; BLOOD CIRCULATION; BLOOD FLOW; BLOOD PRESSURE; COMPUTERIZED TOMOGRAPHY; CONTRAST MEDIA; CORRECTIONS; CORRELATIONS; FEASIBILITY STUDIES; FLUORINE 18; FLUORODEOXYGLUCOSE; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; SCINTISCANNING; STANDARDIZATION; UPTAKE; VASCULAR DISEASES; VOLUME
Descriptors DEC
ANTIMETABOLITES; ARTERIES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TOMOGRAPHY