Published November 2019 | Version v1
Journal article Metadata-only

Prognostic value of the expression of epithelial cell adhesion molecules in head and neck squamous cell carcinoma treated by definitive radiotherapy

Creators

  • 1. Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo (Japan)
  • 2. Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo (Japan)
  • 3. Department of Head and Neck Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji Chuo-ku, Tokyo (Japan)
  • 4. Head and Neck Medical Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo (Japan)
  • 5. Department of Oral Health and Diagnostic Sciences, National Cancer Center Hospital, 5-1-1, Tsukiji Chuo-ku, Tokyo (Japan)

Description

A reliable biomarker can contribute to appropriate treatment selection in the management of head and neck squamous cell carcinoma (HNSCC). Recently, epithelial cell adhesion molecule (EpCAM) was shown to have prognostic features in several malignancies. However, it remains to be elucidated whether EpCAM predicts prognosis of HNSCC after radiotherapy. Therefore, the prognostic potential of EpCAM in HNSCC patients treated by radiotherapy was investigated in this study. All HNSCCs patients examined between January 2013 and December 2015 were analyzed for the expression of EpCAM. One hundred HNSCC patients were identified who were treated by primary radiotherapy. Intense expression of EpCAM was found in 29 HNSCC patients. Two-year overall survival (OS) for patients with intense EpCAM expression was 62.2%, whereas it was 87.9% for those without (P = 0.011). In multivariate analysis, intense EpCAM expression was found to be an independent prognostic factors for OS (P = 0.036). Overall, EpCAM was found to be an independent prognostic factor for HNSCC.

Availability note (English)

Available from http://dx.doi.org/10.1093/jrr/rrz053; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873617

Additional details

Identifiers

URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873617; http://creativecommons.org/licenses/by/4.0/;
DOI
10.1093/jrr/rrz053;

Publishing Information

Journal Title
Journal of Radiation Research
Journal Volume
60
Journal Issue
6
Journal Page Range
p. 803-811
ISSN
0449-3060

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
54118600
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ADHESION; ANTIBODIES; BIOLOGICAL MARKERS; BIOLOGICAL STRESS; CARCINOMAS; EPITHELIUM; GY RANGE 10-100; HEAD; MOLECULES; MULTIVARIATE ANALYSIS; NECK; PATIENTS; RADIOTHERAPY; SIDE EFFECTS; SURVIVAL CURVES
Descriptors DEC
ABSORBED DOSE RANGE; ANIMAL TISSUES; BODY; DISEASES; GY RANGE; MATHEMATICS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; RADIATION DOSE RANGES; RADIOLOGY; STATISTICS; THERAPY

Optional Information

Copyright
Copyright (c) The Author(s) 2019. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.
Notes
PMCID: PMC6873617; PMID: 31361893; PMID: 31361893; PUBLISHER-ID: rrz053; OAI: oai:pubmedcentral.nih.gov:6873617