Improvement in EIS diagnosis accuracy using a multi-frequency parameter analysis method: preliminary results

In this work we assessed the validity of the multi-frequency parameter (MFP) analysis method in distinguishing EIS false positive results. We chose 15 subjects with invasive duct carcinoma as the control group in which EIS results were all positive. In the experiment, three test groups—the Contact, the Skin and the Horm groups—were set to correspond to three common types of EIS false results. In the Contact group, false positive results were induced by poor contact of the measuring probe. In the Skin group, false positive results were induced by skin ridges. In the Horm group, false positive results were induced by a high hormone level. Based on the MFP analysis method, we obtained the Cole–Cole parameters of each subject in the control group and the test groups. Statistical analyses showed there was a significant difference in G0N, G∞N or αN between the control group and the Contact or the Skin group. A significant difference between the control group and the Horm group existed only in αN. These results suggested that by means of the MFP analysis method it was possible to distinguish between a false positive result and a positive result caused by breast cancer. In conclusion, the MFP analysis method appears to be a feasible means to improve the diagnosis accuracy of EIS for breast cancer detection