Spectrophotometric Determination of Mebeverine hydrochloride in pharmaceutical preparation via Ion Association Reaction

We developed colorimetric method to determine Mebeverine hydrochloride. Briefly, the principle of our method is the formation of ion associated complex between the drug and phenol red indicator. The spectrum of the complex was measured with maximum absorption at 396 nm – Beers law is followed over the range over 2 – 25 ug/ml with molar absorptivity of (7.57×10⁴L/Mol. Cm), a sandal sensitivity of (0.00615 μg. Cm ^-2), and the relative standard deviation RSD % (3.3974%), mean recovery was found to be in the range (96-99 %), and correlation coefficient of (R²=0.9941). However, the method accurately and successfully was performed to determine Mebeverine hydrochloride in bulk and pharmaceutical preparations. (paper)