Long term behavior of Am-141 in an adult and a youth

This report summarizes the results of the past six years concerning the investigation of Am-241 metabolism in an adult man and a boy. In vivo whole body, skull, lung, and liver counting techniques are described in detail. The effects of chelation therapy with Na3(Ca-DTPA) are clearly evident. During the time between 1970 and 1976 a 23 percent decrease in body burden for the adult and a 75 percent decrease for the youth were observed. Elimination of Am-241 from liver and lung as a result of chelation therapy accounts for most of the change in total body burden in both cases. Presently the skeletal burdens represent the major fractions of the body burdens, 90 percent for the adult and 75 percent for the youth. Dose estimates for the lung, liver and skeleton are presented on a yearly basis. The practicality of further chelation therapy is discussed in view of the results of previous treatments