Published May 1983 | Version v1
Journal article Metadata-only

Experimental therapy of radiation injury in mice with fetal mesenchym

Creators

  • 1. Laboratorium fuer Experimentelle Radiologie, Neuherberg/Muenchen (Germany, F.R.)

Description

The effects of an intramuscular application of fetal mesenchym (Resistocell) in mice with acute radiation injury was investigated. A single dose of 80 mg/kg body weight one day after radiation exposure (LDsub(70/30), 635 cGy) showed significant therapeutic effects. Further experiments are recommended in order to improve and explain the reported results. (orig.)

Abstract (German)

Fetales Mesenchym (Resistocell) wurde auf seine Wirksamkeit bei akutem Strahlenschaden von Maeusen untersucht. Im therapie-relevanten mitteletalen Dosisbereich (LDsub(70/30) bei 635 cGy) konnte mit einmaliger i.m. Applikation einer Dosis von 80 mg/kg Koerpergewicht 1 Tag nach Bestrahlung ein signifikanter therapeutischer Erfolg erzielt werden. Weitere Versuche zur Optimierung und Erklaerung des Behandlungsresultates werden empfohlen. (orig.)

Additional details

Additional titles

Original title (German)
Untersuchungen ueber die therapeutische Wirkung von fetalem Mesenchym bei akuter Strahlenkrankheit von Maeusen

Publishing Information

Journal Title
Strahlentherapie
Journal Volume
159
Journal Issue
5
Series
CODEN: STRAA.;Strahlentherapie.
Journal Page Range
296-298
ISSN
0039-2073

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
14792088
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
DOSE-RESPONSE RELATIONSHIPS; EARLY RADIATION EFFECTS; HARD X RADIATION; INTRAMUSCULAR INJECTION; MICE; MORTALITY; POST-IRRADIATION THERAPY; RADIATION SYNDROME; RADIOPROTECTIVE SUBSTANCES; SUBLETHAL IRRADIATION; TISSUES; WHOLE-BODY IRRADIATION
Descriptors DEC
ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; INJECTION; INTAKE; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MEDICINE; RADIATION EFFECTS; RADIATIONS; RESPONSE MODIFYING FACTORS; RODENTS; THERAPY; VERTEBRATES; X RADIATION