Effects of insulin-like growth factor-I on bone metabolism in patients with liver cirrhosis
Creators
- 1. Putuo District People's Hospital, Shanghai (China). Dept. of Gastroenterology
Description
To study the effects of serum insulin-like growth factor-I (IGF-I) on bone metabolism in liver cirrhosis, 44 patients with hepatic cirrhosis were divided into 3 groups according to disease severity (Child Pugh Score) and 38 healthy subjects served as controls. Serum levels of IGF-I and osteocalcin(BGP) were measured in all patients and controls. Results showed that levels of IGF-I, BGP, and BMD were lower significantly in patients with liver cirrhosis than that in controls. When the condition of cirrhosis more deteriorated, these changes became much lower significantly. Serum levels of BGP and BMD were positively correlated with IGF-I. The decreasing level of IGF-I might be an important factor causing osteoporosis in patients with liver cirrhosis. (authors)
Additional details
Publishing Information
- Journal Title
- Labeled Immunoassays and Clinical Medicine
- Journal Volume
- 13
- Journal Issue
- 4
- Journal Page Range
- p. 193-195
- ISSN
- 1006-1703
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 39067210
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD SERUM; DIAGNOSIS; GROWTH FACTORS; INSULIN; LIVER; LIVER CIRRHOSIS; METABOLISM; OSTEOPOROSIS; PATIENTS; RADIOIMMUNOASSAY; SKELETON
- Descriptors DEC
- BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DIGESTIVE SYSTEM DISEASES; DISEASES; GLANDS; HORMONES; IMMUNOASSAY; ISOTOPE APPLICATIONS; MATERIALS; MITOGENS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; SKELETAL DISEASES; TRACER TECHNIQUES
Optional Information
- Notes
- 2 tabs., 8 refs.