Published July 2019
| Version v1
Journal article
Synthesis and Anticancer Activity of Thiophene-2-carboxamide Derivatives and In Silico Docking Studies
Creators
- 1. Koneru Lakshmaiah Education Foundation, Department of Chemistry (India)
- 2. School of Pharmacy, Department of Pharmaceutical Chemistry, Gurunanak Institutions Technical Campus (India)
- 3. Guruktupa Institute of Pharmacy, Department of Pharmaceutical Chemistry (India)
Description
A novel series of thiophene-2-carboxamide derivatives are designed and synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectra. The synthesized compounds are evaluated for their in vitro cytotoxic activity by MTT assay. Among the tested compounds, the derivative with 4-Cl-phenyl ring exhibits potent inhibitory activity against MCF-7, K562, HepG2, and MDA-MB-231. The molecular docking study performed for the synthesized compounds against PTP1B exhibits essential key interactions.
Additional details
Identifiers
Publishing Information
- Journal Title
- Russian Journal of General Chemistry
- Journal Volume
- 89
- Journal Issue
- 7
- Journal Page Range
- p. 1502-1512
- ISSN
- 1070-3632
- CODEN
- RJGCEK
INIS
- Country of Publication
- Russian Federation
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 51113603
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- CARBON 13; HYDROGEN 1; IN VITRO; NUCLEAR MAGNETIC RESONANCE; PHOSPHATASES; POLYCYCLIC SULFUR HETEROCYCLES; RINGS; SYNTHESIS; THIOPHENE; TYROSINE
- Descriptors DEC
- AMINO ACIDS; CARBON ISOTOPES; CARBOXYLIC ACIDS; ENZYMES; ESTERASES; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; HYDROLASES; HYDROXY ACIDS; ISOTOPES; LIGHT NUCLEI; MAGNETIC RESONANCE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PROTEINS; RESONANCE; STABLE ISOTOPES
Optional Information
- Copyright
- Copyright (c) 2019 Pleiades Publishing, Ltd.