Significance of determination of the changes in serum level of CXCL10 in patients with graves' disease after radioactive iodine therapy

Objective: To investigate the significance of determination of the changes in serum level of CXCL10 in the patients with Graves' disease after radioactive iodine(¹³¹I) therapy. Methods: Level of serum CXCL10 in the patients with Graves disease, the cured patients treated with ¹³¹I and compared to the normal control group. Serum CXCL10 level was measured by ELISA. The relationship among CXCL10, free triiodothyronine(FT₃) and free thyroxine(FT₄), then made an analysis statistically. Results: The level of CXCL10 in patients with Graves' disease expressed significantly higher than that in the normal control(P < 0.05), meanwhile, CXCL10 in the cured patients decreased significantly(P < 0.05); and CXCL10 was positively correlated with FT₃ and FT₄ (P < 0.05). Conclusion: The level of CXCL10 was correlated with function of thyroid, CXCL10 might be a valuable indicant to evaluate the therapeutic efficacy of Graves' disease after ¹³¹I treatment. (authors)