The effects of ionizing radiation of mammalian cells
Description
In this chapter the authors are concerned with the effects of radiation on dividing cells and the factors that influence the division. In addition, the radical mechanism for radiation damage is briefly reviewed. The mechanism of action of hypoxic cell radiosensitizing drugs is discussed as well as the ability for thiol oxidizing agents to enhance the radiation response. A model for the influence of oxidation-reduction reactions on radiation and damage is examined. The ability of oxygen to increase radiation damage, and the effect of oxygen-sparing drugs on the radiation response of multicellular systems is described. A good deal of emphasis is given in this chapter to oxygen, oxygen-mimicking drugs, and oxygen-sparing drugs because of the central importance of oxygen in radiation effects
Additional details
Publishing Information
- Publisher
- VCH Publishers Inc.
- Imprint Place
- New York, NY (USA)
- ISBN
- 0-89573-127-4
- Imprint Title
- Radiation chemistry
- Imprint Pagination
- 641 p.
- Journal Page Range
- p. 527-564.
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 21067207
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; DRUGS; IONIZING RADIATIONS; OXYGEN; RADIATION CHEMISTRY; RADIOSENSITIVITY; THIOLS
- Descriptors DEC
- BIOLOGICAL EFFECTS; CHEMISTRY; ELEMENTS; NONMETALS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATION EFFECTS; RADIATIONS