Amount of mobilizable stem cells in perturbed hemopoiesis
Creators
- 1. Frederic Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary
Description
The level of mobilizable 9-day colony-forming units (CFU-s), which represents a constant fraction of the normal mouse bone marrow CFU-s pool, was assayed in BDF1 mice with perturbed hemopoiesis (i.e., during increased turnover of CFU-s or increased CFU-s traffic after irradiation). After low-level irradiation, regeneration of the mobilizable CFU-s fraction was significantly slower than that of bone marrow CFU-s. Depletion of the mobilizable CFU-s pool was observed if a permanently increased outflow of CFU-s from the bone marrow was induced by endotoxin injection. After 40% withdrawal of the blood volume, the mobilizable CFU-s pool expanded marginally. Assuming that the level of mobilizable CFU-s is a consequence of production and outflow from the bone marrow compartment, changes in the pool size of mobilizable CFU-s may be a sensitive indicator of balanced or unbalanced hemopoiesis
Additional details
Publishing Information
- Journal Title
- Int. J. Cell Cloning
- Journal Issue
- no.3
- Series
- Int. J. Cell Cloning.
- CODEN
- IJCCE
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 17016310
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REGENERATION; BLOOD; BONE MARROW CELLS; ENDOTOXINS; GAMMA RADIATION; HEMATOPOIETIC SYSTEM; MICE
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; ANTIGENS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MAMMALS; MATERIALS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; TOXINS; VERTEBRATES