Research progress of multimodal MRI in evaluation of Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disease. Pathological changes mainly include degeneration and necrosis of dopaminergic neurons and formation of Lewy bodies in the nigrostriatal striatum pathway, resulting in a series of motor and non-motor symptoms. In recent years, with the development in multimodality MRI and brain network analysis, especially structural brain networks based on structural MRI, diffusion tensor imaging, and functional brain network based on functional MRI, the brain structure and functional changes of different PD subtypes can be studied from different aspects. This article reviews the researches on different PD subtypes based on multimodal MRI brain network imaging technology. (authors)