Automatic and speedy synthesis of 18F-FDG
Creators
- 1. The PLA General Hospital, Beijing (China). Dept. of Nuclear Medicine
Description
Objective: To make a simple device for automatic synthesis of 18F-FDG. Methods: The 18F was processed by azeotropic drying with anhydrous acetonitrile using hot air bath at the temperature of 116 degree C for two times. Subsequently triflate precursor was added at an air bath temperature of 85-90 degree C for 3-5 min. Acetonitrile was evaporated at 116 degree C. The residue was cooled down to 40 degree C with air bath and the residue was dissolved in 2 mL 0.3 mol/L NaOH for 2 min. The aqueous solution was neutralized and purified with Dowex-50W/ AG11A8 resin and Alumin-N, C-18 column. Results: The device can synthesize 18F-FDG within 20 min, and the radiochemical yield was 61% [42%-70%, n=60, end of synthesis (EOS)]. Conclusion: The technology and automatic device can synthesize 18F-FDG with high yield within a short time, and it can be used in PET centers
Additional details
Publishing Information
- Journal Title
- Chinese Journal of Nuclear Medicine
- Journal Volume
- 23
- Journal Issue
- 1
- Journal Page Range
- p. 52-54
- ISSN
- 0253-9780
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 35063218
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- AUTOMATION; CHEMICAL PREPARATION; FLOWSHEETS; FLUORINE 18; GLUCOSE; QUALITY CONTROL; RADIOPHARMACEUTICALS; TECHNOLOGY ASSESSMENT
- Descriptors DEC
- ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOHYDRATES; CONTROL; DIAGRAMS; DRUGS; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; INFORMATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MONOSACCHARIDES; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SACCHARIDES; SYNTHESIS