Published February 1994 | Version v1
Journal article Metadata-only

Radioiodination of 2'-deoxyuridine: preparation and preliminary evaluation in tumour-bearing rats

Creators

  • 1. Gent Univ. (Belgium). Inst. for Nuclear Sciences
  • 2. University Hospital, Gent (Belgium). Dept. of Radiotherapy and Nuclear Medicine

Description

A simple rapid procedure, using a Iodo-bead as oxidizing agent, has been developed for labelling 2'-deoxyuridine on the 5-position of the base with 123I. The labelling yield exceeds 60% and the total production time amounts to only 1 h. Biodistribution studies with 5-[123I]iodo-2'-deoxyuridine on tumour-bearing rats showed an important uptake of activity in tissue with a high cell proliferation rate (tumour, intestine) and in the liver. (author)

Additional details

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
45
Journal Issue
2
Journal Page Range
p. 149-153.
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
25046744
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CHEMICAL PREPARATION; DEOXYURIDINE; IODINE 123; LABELLING; RADIOPHARMACEUTICALS; RATS; TISSUE DISTRIBUTION; UPTAKE
Descriptors DEC
ANIMALS; ANTIMETABOLITES; AZINES; BETA DECAY RADIOISOTOPES; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; NUCLEOSIDES; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RIBOSIDES; RODENTS; SYNTHESIS; URACILS; VERTEBRATES