Mutation research with ionizing radiations and chemicals using drosophila: problems, results and perspectives

The results of mutagenesis studies with Drosophila are examined in order to inquire the extent to which the genetic responses to ionizing radiations and to chemical mutagens share common features, to identify those findings that may have validity beyond the confines of this species, and to assess the contributions and implications of Drosophila results to the problems of mutagenicity testing and of the evaluation of genetic hazards to man from exposure to environmental chemicals. The results obtained in the studies permit the estimation of X-irradiation equivalent doses of EMS for the induction of sex-linked recessive lethals and specific locus mutations in mature spermatozoa. (Auth.)