Published November 1982 | Version v1
Journal article Metadata-only

Labeling studies of proteins using bifunctional chelates: the desferrioxamine-human serum albumin (DF-HSA) conjugate

Creators

  • 1. University of Southern California, Los Angeles (USA)

Description

Coupling the chelating agent desferrioxamine-mesylate (DF) to human serum albumin, using either ethy-(dimethylaminopropyl) carbodiimide (ECD) or glutaraldehyde (GL) has been carried out. The MSA-DF conjugates were radiolabelled with 67Ga citrate and treated with urea to increase labelling efficiency. Biodistribution and blood clearance were studied in rabbits using a scintillation camera. (U.K.)

Additional details

Publishing Information

Journal Title
J. Labelled Compd. Radiopharm.
Journal Volume
19
Journal Issue
11-12
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
1405-1407

Conference

Title
4. International symposium on radiopharmaceutical chemistry.
Dates
23-27 Aug 1982.
Place
Juelich (Germany, F.R.).

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
14778360
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ALBUMINS; ALDEHYDES; BLOOD SERUM; BLOOD-PLASMA CLEARANCE; CHELATING AGENTS; CHEMICAL PREPARATION; CHROMATOGRAPHY; DEFEROXAMINE; DISTRIBUTION; GALLIUM 67; GLUTARIC ACID; IMIDES; IODINE 125; LIVER; PH VALUE; RABBITS; RADIOACTIVITY; RADIOPHARMACEUTICALS; SCINTILLATION COUNTING; STABILITY; TECHNETIUM 99; UREA
Descriptors DEC
AMINES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; CARBONIC ACID DERIVATIVES; CARBOXYLIC ACIDS; CLEARANCE; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DICARBOXYLIC ACIDS; DIGESTIVE SYSTEM; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GALLIUM ISOTOPES; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES; SYNTHESIS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES