Local reactions of the oral and pharyngeal mucosa in radio- and chemotherapy of head and neck tumours

Local radiation effects of the oral, pharyngeal and laryngeal mucosa were studied on the material covering 518 patients with malignant tumours of the head and the neck. As a results of the studies it was established that occurrence and the degree of intensity increase and terms of radioepithelitis development become reduced with an increase of single fractions; all kinds of local radiation effects develop at earlier periods and with a smaller cumulative dose in combination of radiation therapy with chemotherapy. As a result of early prophylactic measures and thorough assanation of the oral cavity radioepithelitis incidence decreases and the degree of its intensity lowers