Published October 1977 | Version v1
Journal article Metadata-only

Cell inactivation effects of fast neutrons produced by NIRS cyclotron on murine lymphoma (L5178Y) cells in vitro

Creators

  • 1. National Inst. of Radiological Sciences, Chiba (Japan)

Description

Cell inactivation effects of x- and fast neutron irradiation on murine lymphoma L5178Y cells were investigated by means of soft agar colony formation technique. The fast neutrons were produced by 9Be(d, n) B10 reactions at dE of 30 MeV in NIRS cyclotron. X-ray survival parameters were Do=88.8 rad, Dq=115.4 rad, and n=3.6 and that of fast neutrons were 65.5 rad, 66.8 rad and 2.8 respectively. Relative biological effectiveness (Do ratio of fast neutrons against x-rays) was calculated to be 1.33. A great decrease in Dq dose after fast neutron irradiation suggests decreased capacity of sublethal damage in the cells and thereby only small fraction of cells could recover. (auth.)

Additional details

Publishing Information

Journal Title
Nippon Igaku Hoshasen Gakkai Zasshi
Journal Volume
37
Journal Issue
10
Series
Nippon Igaku Hoshasen Gakkai Zasshi.
Journal Page Range
976-978

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
9391660
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; COMPARATIVE EVALUATIONS; CYCLOTRONS; FAST NEUTRONS; IN VITRO; INACTIVATION; LYMPHOMAS; MICE; RBE; SURVIVAL CURVES; TUMOR CELLS; VAN DE GRAAFF ACCELERATORS
Descriptors DEC
ACCELERATORS; ANIMAL CELLS; ANIMALS; BARYONS; BIOLOGICAL EFFECTS; CYCLIC ACCELERATORS; DISEASES; ELECTROSTATIC ACCELERATORS; ELEMENTARY PARTICLES; FERMIONS; HADRONS; MAMMALS; NEOPLASMS; NEUTRONS; NUCLEONS; RADIATION EFFECTS; RODENTS; VERTEBRATES