Published December 2001
| Version v1
Journal article
Organ and tissue distribution of phencyclidine in the rat
- 1. Showa Pharmaceutical Univ., Machida, Tokyo (Japan)
Description
The excretion, distribution and metabolism of 3H-phencyclidine (PCP) were studied in male rats following oral administration. The radioactivity was mainly excreted in urine and to a lesser extent in feces. Most of the urinary radioactivity was excreted in the form of glucuronide conjugates of hydroxylated PCP metabolites and urinary excretion of unchanged PCP was minimal. Distribution study showed no marked affinity for any particular tissue, although the levels in liver and prostate were a little high within 24 h after dosing. PCP was detected in brain by GC-MS. (author)
Additional details
Publishing Information
- Journal Title
- Radioisotopes (Tokyo)
- Journal Volume
- 50
- Journal Issue
- 12
- Journal Page Range
- p. 612-617
- ISSN
- 0033-8303
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 33008574
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BRAIN; DAILY VARIATIONS; EXCRETION; FECES; INTESTINES; LIVER; MUSCLES; PIPERIDINES; RADIOACTIVITY; RADIONUCLIDE KINETICS; RATS; TISSUE DISTRIBUTION; TRITIUM; URINE
- Descriptors DEC
- AMINES; ANIMALS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CENTRAL NERVOUS SYSTEM; CLEARANCE; DIGESTIVE SYSTEM; DISTRIBUTION; GASTROINTESTINAL TRACT; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; ISOTOPES; KINETICS; LIGHT NUCLEI; MAMMALS; MATERIALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIDINES; RADIOISOTOPES; RODENTS; VARIATIONS; VERTEBRATES; WASTES; YEARS LIVING RADIOISOTOPES