Published July 1995 | Version v1
Journal article Metadata-only

The influence of NS-1539, a potential antiirradiation agent on the DNA repair synthesis caused by chemical mutagen N-nitroso-methylurea and radiation

Creators

Description

The influence of NS-1539, a potential antiirradiation agent and indole analogues of tamoxifen on the DNA repair synthesis in the bone marrow and lymphocytes of periferal blood was studied. It was found that the DNA repair processes from damages caused by chemical mutagen N-nitroso-N-methylurea or physical factor UV-irradiation in the bone marrow cells after the NS-1539 protection of mice as well as in lymphocytes of periferal blood of human donors were enhanced. 10 refs

Additional details

Additional titles

Original title (Russian)
Влияние потенциального противолучевого средства — соединения NS-1539 — на репаративный синтез ДНК, индуцируемый повреждающим действием химического мутагена N-нитрозо-N-метилмочевины и излучений

Publishing Information

Journal Title
Radiatsionnaya Biologiya, Radioehkologiya
Journal Volume
35
Journal Issue
4
Journal Page Range
p. 528-535.
ISSN
0869-8031
CODEN
RBIREJ

INIS

Country of Publication
Russian Federation
Country of Input or Organization
Russian Federation
INIS RN
27021969
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; BIOSYNTHESIS; BONE MARROW; CELL CULTURES; DNA; GAMMA RADIATION; IN VITRO; IN VIVO; LYMPHOCYTES; MAN; MICE; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; TIME DEPENDENCE; ULTRAVIOLET RADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DRUGS; ELECTROMAGNETIC RADIATION; HEMATOPOIETIC SYSTEM; IONIZING RADIATIONS; LEUKOCYTES; MAMMALS; MATERIALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PRIMATES; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; SYNTHESIS; TISSUES; VERTEBRATES