The dynamic change of endothelial cell, endothelin and 6-K-PGF1α in circulating blood of the patients with coronary heart disease
Creators
- 1. Shanghai Railway Medical College, Shanghai (China). Affiliated Ganquan Hospital
Description
With the circulating endothelial cell (CEC) as an indicator of vessel endothelial cell (VEC) injury, and plasma endothelin (ET) and prostaglandin F1α (PGI2) reflecting the functional change of the VEC, a comparative study between 85 patients with coronary heart disease and 30 normal health, and also a dynamic observation of 50 patients with unstable angina pectoris and 20 patients with acute myocardial infarction (AMI) were reported. The result showed that in patients with coronary heart disease, peripheral blood circulating CEC and ET level was increased (P<0.001), while the PGI2 decreased (P<0.01). All these were more significant in patients with unstable angina pectoris and myocardial infarction, and its magnitude correlated closely with the severity of the disease. All these showed that the VEC injury and the imbalance of its endothelial relaxing and contracting factors have played an important role in the pathogenesis of coronary heart disease
Additional details
Publishing Information
- Journal Title
- Nuclear Techniques
- Journal Volume
- 18
- Journal Issue
- 11
- Journal Page Range
- p. 659-662.
- ISSN
- 0253-3219
- CODEN
- NUTEDL
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 27031493
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD; BLOOD CHEMISTRY; CARDIOVASCULAR DISEASES; COMPARATIVE EVALUATIONS; DIAGNOSIS; ENDOTHELIUM; MYOCARDIAL INFARCTION; RADIOIMMUNOASSAY
- Descriptors DEC
- BIOCHEMISTRY; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CHEMISTRY; DISEASES; EVALUATION; IMMUNOASSAY; ISOTOPE APPLICATIONS; MATERIALS; RADIOASSAY; TISSUES; TRACER TECHNIQUES