The development of [18F]cyclofoxy as a ligand for imaging opioid receptors in the CNS of conscious humans
Creators
- Rice, K.C.1
- Newman, A.H.1
- Ostrowski, N.L.1
- Cohen, R.M.1
- Pert, A.1
- Pert, C.B.1
- Burke, T.R. Jr.1
- McLellan, C.A.1
- Channing, M.A.1
- Finn, R.D.1
- Dunn, B.1
- Simpson, N.1
- Carson, R.W.1
- Larson, S.M.1
- Eckelman, W.C.1
- Bennett, J.M.1
- Kawai, R.1
- Sawada, Y.1
- Herscovitch, P.1
- Yolles, P.S.1
- Nordhal, T.1
- Gross, M.1
- Blasberg, R.1
- 1. National Institutes of Health, Bethesda, MD (USA)
Description
Positron emission tomography (PET) is a unique, noninvasive technique applicable to real time visualization and quantitation of drug receptor occupancy in the brain of conscious humans. Such studies with the normal and abnormal human CNS can potentially provide insight into the biochemical basis of disease states and the effects of drug therapy. The (-)-enantiomer of cyclofoxy, a fluorinated, potent narcotic antagonist derived from naltrexone, has been developed at NIH as an agent for study of the opioid receptor-endorphin system using PET. The development and current status of this program is described, including application of the NIH Opiate Total Synthesis for production the pharmacologically inert (+)-[18F]cyclofoxy required for quantitation of receptor occupancy
Additional details
Publishing Information
- Publisher
- American Chemical Society.
- Imprint Place
- Washington, DC (USA)
- Imprint Title
- The 1989 international chemical congress of Pacific Basin Societies: Abstracts of papers, Parts I and II
- Imprint Pagination
- 1700 p.
- Journal Page Range
- p. 1100, Paper ORGN 595.
Conference
- Title
- International chemical congress of Pacific Basin Societies (PACIFICHEM '89).
- Dates
- 17-22 Dec 1989.
- Place
- Honolulu, HI (USA).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 22049801
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- CENTRAL NERVOUS SYSTEM AGENTS; CHEMICAL PREPARATION; FLUORINE 18; LIGANDS; MEASURING METHODS; POSITRON COMPUTED TOMOGRAPHY; RADIOISOTOPES
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COMPUTERIZED TOMOGRAPHY; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; SYNTHESIS; TOMOGRAPHY
Optional Information
- Secondary number(s)
- CONF-891206--.