Synthesis, characterization and biological activities of organotin(iv) complexes with 2-thioazoline-2-thiol
Creators
- 1. Government College University, Islamabad (Pakistan). Dept. of Chemistry
- 2. Quaid-e-Azam University, Islamabad (Pakistan). Dept. of Chemistry
- 3. University of Sargodha Lyallpur Campus, Faisalabad (Pakistan). Dept. of Chemistry
Description
Six complexes of 2-thiazoline-2-thiol (HL) with triorganotin(IV) and chlorodiorganotin(IV), [R3SnL {R = CH3 (1), n-C4H9 (2) C6H5 (3)}; R2SnClL {R = CH3 (4), n-C4H9 (5) C6H5 (6)}], have been synthesized and characterized by elemental analysis, FT-IR and multinuclear NMR (1H and 13C) spectroscopy and mass spectrometry. Spectroscopic studies revealed that ligand act as monodentate. NMR data suggested that tin atom is tetra-coordinated in triorganotin(IV) complexes (1-3). The biological screening results show that complexes exhibited strong antibacterial and antifungal activity. Biofilm inhibition activity of these complexes was also found satisfactory. The in vitro hemolytic activity data showed that these complexes are least cytotoxic. (author)
Additional details
Publishing Information
- Journal Title
- Journal of the Chemical Society of Pakistan
- Journal Volume
- 40
- Journal Issue
- 1
- Journal Page Range
- p. 213-224
- ISSN
- 0253-5106
INIS
- Country of Publication
- Pakistan
- Country of Input or Organization
- Pakistan
- INIS RN
- 49051008
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- ANTIMICROBIAL AGENTS; COMPLEXES; FUNGI; HEMOLYSIS; IN VITRO; INFRARED SPECTRA; INHIBITION; LIGANDS; MASS SPECTROSCOPY; SYNTHESIS; TIN COMPOUNDS
- Descriptors DEC
- ANTI-INFECTIVE AGENTS; CHEMICAL REACTIONS; DECOMPOSITION; DRUGS; LYSIS; PATHOLOGICAL CHANGES; PLANTS; SPECTRA; SPECTROSCOPY