3H-apomorphine labels both dopamine postsynaptic receptors and autoreceptors

Results are reported demonstrating that 3H-apomorphine labels two classes of dopamine (DA) receptor, distinguishable using domperidone, a selective DA antagonist. Lesion studies indicate that they correspond to a certain class of postsynaptic receptor and to autoreceptors, respectively. Each of these classes display a clearly distinct pharmacological specificity for antipsychotics and DA agonists. (U.K.)