Clinical observation of hydrogen-water on the treatment of acute radiation-induced oral mucositis of 110 cases

Objective: To observe the clinical effects of hydrogen-water on the treatment of acute radiation-induced oral mucositis. Methods: The 110 patients with nasopharyngeal carcinoma were randomly divided into treatment group and control group. There were 55 cases in the treatment group and 55 cases in the control group. The treatment group was treated with hydrogen-rich water, while the control group was treated with normal saline until the end of radiotherapy. The clinical symptoms and signs of change, acute radiation oropharyngeal mucosa reaction, swallowing function and the pain degree of oral mucosa were evaluated at the 2, 4 and 6 weeks of radiotherapy. Results: The acute radiation induced mucosa reaction of treatment group at the 4, 6 weeks of treatment was significantly more slight than control group (P < 0.05). The improvement of swallowing function and the remission of oral mucosa pain in treatment group at the 4, 6 weeks of radiotherapy were better than that in control group (P < 0.05). Conclusion: Hydrogen-rich water can improve radiation oral mucosa reaction. (authors)