Published October 2000
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Glioblastoma, gadolinium (III) and NCT. An in vitro study
Creators
- 1. CNR, Institute of Neurobiology and Institute of Cell Biology, Roma (Italy)
- 2. ENEA, Radiobiology Dept., Roma (Italy)
- 3. UCSC, Institute of Neurosurgery, Rome (Italy)
- 4. Univ. of Wisconsin-Madison, WI (United States)
Description
We treated cultured human glioblastoma cells with gadolinium (III) [gadopentetic acid] and we found that: a) cells do internalise this element; b) gadolinium can be localised in the cells nuclei; c) exposure of the cultures to a neutron beam produced a significant and immediate cell death. Although cell survival was also influenced in the irradiated controls it was further reduced (about 50%) in cells pre-exposed to 10 mg/ml gadopentetic acid. We also found that Gd uptake, as measured by ICP-AES, was concentration dependent. (author)
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Additional details
Publishing Information
- Imprint Title
- Proceedings of the ninth international symposium on neutron capture therapy for cancer
- Imprint Pagination
- 369 p.
- Journal Page Range
- p. 219-220
- Report number
- KURRI-KR--54
Conference
- Title
- 9. international symposium on neutron capture therapy for cancer
- Dates
- 2-6 Oct 2000
- Place
- Osaka (Japan)
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 33014446
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; BORON 10; CALIFORNIUM 252; CELL CULTURES; CELL KILLING; GADOLINIUM; GADOLINIUM 157; GLIOMAS; ICP MASS SPECTROSCOPY; IN VITRO; IRRADIATION; NEUTRON CAPTURE THERAPY; THERMAL NEUTRONS; TUMOR CELLS; UPTAKE
- Descriptors DEC
- ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; ANIMAL CELLS; BARYONS; BIOLOGICAL EFFECTS; BORON ISOTOPES; CALIFORNIUM ISOTOPES; DISEASES; ELEMENTARY PARTICLES; ELEMENTS; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; FERMIONS; GADOLINIUM ISOTOPES; HADRONS; HEAVY NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPES; LIGHT NUCLEI; MASS SPECTROSCOPY; MEDICINE; METALS; NEOPLASMS; NERVOUS SYSTEM DISEASES; NEUTRON THERAPY; NEUTRONS; NUCLEAR MEDICINE; NUCLEI; NUCLEONS; ODD-ODD NUCLEI; RADIATION EFFECTS; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; RARE EARTH NUCLEI; RARE EARTHS; SPECTROSCOPY; SPONTANEOUS FISSION RADIOISOTOPES; STABLE ISOTOPES; THERAPY; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- 10 refs., 3 figs.