Published 1976 | Version v1
Report Open

Dimercaptosuccinic acid-Tc99m: Preparation and biodistribution in rats

Creators

Description

Owing to the juxtaposition of 4 ligands (2 SH groups + 2 COOH groups), dimercaptosuccinic acid has a strong chelating capacity which suits it for technetium 99 m labelling. The study is carried out in 2 stages: preparation and stability of the dimercaptosuccinic acid - stannous chloride complex (DMSA-Sn); biodistribution of DMSA-Sn-Tc99m complex in rats as a function of the following parameters: pH, relative stannous chloride and dimercaptosuccinic acid concentrations, TcO4 volume added, injection time after labelling. The strong activity uptake obtained in rat kidneys represents a considerable step forward in the radioisotopic kidney examination and offers the prospect of clinical use

Abstract (French)

La juxtaposition de 4 ligands dans l'acide dimercaptosuccinique (2 groupements SH + 2 groupements COOH) lui confere un puissant pouvoir chelateur qui permet son marquage au Technetium 99m. L'etude comporte 2 parties. Preparation et stabilite du complexe acide dimercaptosuccinique-chlorure stanneux (DMSA-Sn); biodistribution chez le rat du complexe DMSA-Sn-Tc99m en fonction des parametres suivants: pH, concentrations relatives en chlorure stanneux et acide dimercaptosuccinique, volume de TcO4 ajoute, delai d'injection apres marquage. La forte captation de l'activite par les reins obtenue chez le rat constitue un progres appreciable dans l'examen radioisotopique du rein et permet de prevoir son utilisation clinique

Files

8300909.pdf

Files (985.7 kB)

Name Size Download all
md5:2dec71a381765cfa915ff688cbc79067
985.7 kB Preview Download

Additional details

Additional titles

Original title (French)
Acide dimercaptosuccinique-Tc99m. Preparation et biodistribution chez le rat

Publishing Information

ISBN
2727200064
Imprint Title
Renal mercury and DMSA uptake
Imprint Pagination
p. 189-200.
Report number
CEA-CR--8

Conference

Title
2. International colloquium on radioactive Hg renal uptake.
Dates
24 Oct 1975.
Place
Paris, France.

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
8300909
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S60: APPLIED LIFE SCIENCES;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BIOLOGICAL LOCALIZATION; CHEMICAL PREPARATION; KIDNEYS; RADIOPHARMACEUTICALS; RATS; STABILITY; SUCCINIC ACID; TECHNETIUM 99; TIN COMPLEXES; UPTAKE
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; COMPLEXES; DICARBOXYLIC ACIDS; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SYNTHESIS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
Imprint:La fixation renale du mercure et du DMSA.;Compte rendu du 2. Colloque international. Paris, 24-25 octobre 1975.