Published August 1993 | Version v1
Journal article Metadata-only

Uracil-DNA glycosylase produces excess lethal damage induced by an Auger cascade in BrdU-labelled bacteriophage T1

Creators

  • 1. Tokai Univ., Isehara, Kanagawa (Japan). School of Medicine
  • 2. Kobe Univ. (Japan). School of Medicine
  • 3. National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan)
  • 4. Rikkyo Univ., Tokyo (Japan). Faculty of Science

Description

T1 phages with and without 5-bromo-2'-deoxyuridine (BrdU) labelling were irradiated in solids with monochromatic X-rays at 12.40 and 13.51 keV, below and just above the K-absorption edge of bromine (13.47 keV) in vacuum and wet states. Irradiated phages were assayed on uracil-DNA glycosylase (Udg) deficient (ung-1) and sufficient (ung+) host strains of Escherichia coli, in order to investigate the nature of the lethal damage induced by Auger cascade following X-ray absorption at the K-shell of bromine as a key atom. (Author)

Additional details

Publishing Information

Journal Title
International Journal of Radiation Biology
Journal Volume
64
Journal Issue
2
Journal Page Range
p. 157-164.
ISSN
0955-3002
CODEN
IJRBE7

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
25014437
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
AUGER EFFECT; BACTERIOPHAGES; BIOLOGICAL RADIATION EFFECTS; BUDR; GLYCOSYL HYDROLASES; K ABSORPTION; KEV RANGE 10-100; LABELLED COMPOUNDS; RESPONSE MODIFYING FACTORS; URACILS; X RADIATION
Descriptors DEC
ABSORPTION; ANTIMETABOLITES; AZINES; BIOLOGICAL EFFECTS; BROMOURACILS; DRUGS; ELECTROMAGNETIC RADIATION; ENERGY RANGE; ENZYMES; HETEROCYCLIC COMPOUNDS; HYDROLASES; HYDROXY COMPOUNDS; IONIZING RADIATIONS; KEV RANGE; MICROORGANISMS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC BROMINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PARASITES; PROTEINS; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; RIBOSIDES; SORPTION; VIRUSES