Imaging dose in breast radiotherapy: does breast size affect the dose to the organs at risk and the risk of secondary cancer to the contralateral breast?
Creators
- 1. South Western Clinical School, University of New South Wales, Sydney, New South Wales (Australia)
- 2. Liverpool Cancer Therapy Centre and Ingham Institute, Liverpool, New South Wales (Australia)
- 3. Centre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales (Australia)
- 4. School of Medicine, University of Western Sydney, New South Wales (Australia)
- 5. Collaboration for Cancer Outcomes Research and Evaluation, Liverpool Hospital, Liverpool, New South Wales (Australia)
- 6. School of Physics, University of Sydney, Sydney, New South Wales (Australia)
Description
Correct target positioning is crucial for accurate dose delivery in breast radiotherapy resulting in utilisation of daily imaging. However, the radiation dose from daily imaging is associated with increased probability of secondary induced cancer. The aim of this study was to quantify doses associated with three imaging modalities and investigate the correlation of dose and varying breast size in breast radiotherapy. Planning computed tomography (CT) data sets of 30 breast cancer patients were utilised to simulate the dose received by various organs from a megavoltage computed tomography (MV-CT), megavoltage electronic portal image (MV-EPI) and megavoltage cone-beam computed tomography (MV-CBCT). The mean dose to organs adjacent to the target volume (contralateral breast, lungs, spinal cord and heart) were analysed. Pearson correlation analysis was performed to determine the relationship between imaging dose and primary breast volume and the lifetime attributable risk (LAR) of induced secondary cancer was calculated for the contralateral breast. The highest contralateral breast mean dose was from the MV-CBCT (1.79 Gy), followed by MV-EPI (0.22 Gy) and MV-CT (0.11 Gy). A similar trend was found for all organs at risk (OAR) analysed. The primary breast volume inversely correlated with the contralateral breast dose for all three imaging modalities. As the primary breast volume increases, the likelihood of a patient developing a radiation-induced secondary cancer to the contralateral breast decreases. MV-CBCT showed a stronger relationship between breast size and LAR of developing a radiation-induced contralateral breast cancer in comparison with the MV-CT and MV-EPI. For breast patients, imaging dose to OAR depends on imaging modality and treated breast size. When considering the use of imaging during breast radiotherapy, the patient's breast size and contralateral breast dose should be taken into account
Availability note (English)
Available from http://dx.doi.org/10.1002/jmrs.91; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364804Additional details
Identifiers
Publishing Information
- Journal Title
- Journal of Medical Radiation Sciences (Print)
- Journal Volume
- 62
- Journal Issue
- 1
- Journal Page Range
- p. 32-39
- ISSN
- 2051-3895
INIS
- Country of Publication
- Australia
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 46108120
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOMEDICAL RADIOGRAPHY; COMPUTERIZED TOMOGRAPHY; CONES; HAZARDS; IMAGES; LUNGS; MAMMARY GLANDS; NEOPLASMS; PATIENTS; PLANNING; POSITIONING; RADIATION DOSES; RADIOTHERAPY; SPINAL CORD
- Descriptors DEC
- BODY; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; DOSES; GLANDS; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RESPIRATORY SYSTEM; THERAPY; TOMOGRAPHY
Optional Information
- Copyright
- Copyright (c) 2015 The Authors. Journal of Medical Radiation Sciences published by Wiley Publishing Asia Pty Ltd on behalf of Australian Institute of Radiography and New Zealand Institute of Medical Radiation Technology.
- Notes
- PMCID: PMC4364804; PMID: 26229665; OAI: oai:pubmedcentral.nih.gov:4364804