The influence of ionizing radiation at the alkaline phosphatase activity and calcium 45 transport under hypothyroid conditions

The experiments with 2-month-old hypothyroid male rats (mercasolil 10 mg/kg per os during 21 days) have shown that total gamma-irradiation ( 0,5 Gy) caused phased changes of alkaline phosphatase - its reduction in the first dates of the investigation (3, 10 and 30 days), normal activity in a 90 days and repeated drop of the activity at the end of the experiment (180 days). In a 3 and 10 days after irradiation it was revealed the diminish of the calcium-accumulated ability of the duodenum mucous membrane in the hypothyroid rats. So it was concluded that combined action of radiation and mercasolil leaded to a decrease in calcium 45 transport in the duodenum and reduction in the activity of thermo labile isoenzyme of alkaline phosphatase in blood serum