Estimated human absorbed dose of ¹⁷⁷Lu–BPAMD based on mice data: Comparison with ¹⁷⁷Lu–EDTMP

In this work, the absorbed dose of human organs for ¹⁷⁷Lu–BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with ¹⁷⁷Lu–EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both ¹⁷⁷Lu–BPAMD and ¹⁷⁷Lu–EDTMP is observed on the bone surface with 8.007 and 4.802 mSv/MBq. Generally, ¹⁷⁷Lu–BPAMD has considerable characteristics compared with ¹⁷⁷Lu–EDTMP and can be considered as a promising agent for the bone pain palliation therapy. - Highlights: • ¹⁷⁷Lu–BPAMD complex was prepared in high radiochemical purity (>93%, ITLC). • The highest absorbed dose for ¹⁷⁷Lu–BPAMD is observed in the bone (8.007 mSv/MBq). • All tissues receive insignificant absorbed dose in comparison with bone tissue. • ¹⁷⁷Lu–BPAMD has considerable characteristics compared to ¹⁷⁷Lu–EDTMP. • ¹⁷⁷Lu–BPAMD can be considered as a promising agent for bone pain palliation therapy