DOTATOC: a powerful new tool for receptor-mediated radionuclide therapy
Creators
- 1. Institute of Nuclear Medicine, University Hospital, School of Medicine, Basel (Switzerland)
- 2. Department of Internal Medicine, University Hospital, School of Medicine, Basel (Switzerland)
- 3. Department of Radiological Physics, University Hospital, School of Medicine, Basel (Switzerland)
Description
This study presents the first successful use of a peptidic vector, DOTATOC, labelled with the β-emitting radioisotope yttrium-90, for the treatment of a patient with somatostatin receptor-positive abdominal metastases of a neuroendocrine carcinoma of unknown localization. Tumour response and symptomatic relief were achieved. In addition, the new substance DOTATOC was labelled with the diagnostic chemical analogue indium-111 and studied in three patients with histopathologically verified neuroendocrine abdominal tumours for its diagnostic sensitivity and compared with the commercially available OctreoScan. In all patients the kidney-to-tumour uptake ratio (in counts per pixel) was on average 1.9-fold lower with 111In-DOTATOC than with OctreoScan. DOTATOC could be a potential new diagnostic and therapeutic agent in the management of neuroendocrine tumours. (orig.). With 4 figs., 1 tab
Additional details
Publishing Information
- Journal Title
- European Journal of Nuclear Medicine
- Journal Volume
- 24
- Journal Issue
- 7
- Journal Page Range
- p. 792-795.
- ISSN
- 0340-6997
- CODEN
- EJNMD9
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 28055150
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ABDOMEN; DTPA; IMAGES; INDIUM 111; METASTASES; RADIOTHERAPY; YTTRIUM 90
- Descriptors DEC
- AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; BODY AREAS; CARBOXYLIC ACIDS; CHELATING AGENTS; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; THERAPY; YTTRIUM ISOTOPES