Published May 1996 | Version v1
Journal article Metadata-only

Evaluation of livertaxis of antiviral drug NGA-ACV and its mechanism

Creators

  • 1. West China Univ. of Medical Sciences, Chengdu (China)

Description

Livertaxis of antiviral drug galactosyl-neoglycoalbumin-(NGA)-acyclovir(ACV) and its mechanism are assessed by using radioactive tracer technique. NGA was a synthetic ligand specific for asialoglycoprotein receptor, which existed in the mammalian liver only. NGA as a carrier of hepatic targeting drugs was coupled with an antiviral drugs ACV via a butanediamide bridge to form a conjugator NGA-ACV. NGA-ACV was labelled with 131I. The data of distribution in mice, animal (rabbit and chicken) and HPLC assay were obtained. NGA-ACV had remarkable livertaxis and its uptake in liver was over 80% with the feature of receptor-mediated binding to hepatocytes in vivo. NGA-ACV is a potential receptor-mediated hepatic targeting antiviral drug

Additional details

Publishing Information

Journal Title
Chinese Journal of Nuclear Medicine
Journal Volume
16
Journal Issue
2
Journal Page Range
p. 116-118.
ISSN
0253-9780
CODEN
CITCDE

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
27061531
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ANTI-INFECTIVE AGENTS; CHICKENS; CONTRAST MEDIA; GALACTOSE; GLYCOPROTEINS; HEPATITIS; IODINE 131; LABELLING; LIVER CELLS; NUCLEAR MOLECULES; PHARMACOLOGY; RADIOISOTOPE SCANNING; TISSUE DISTRIBUTION; TRACER TECHNIQUES; VIRAL DISEASES
Descriptors DEC
ALDEHYDES; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIRDS; CARBOHYDRATES; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM DISEASES; DISEASES; DISTRIBUTION; DRUGS; FOWL; HEXOSES; INFECTIOUS DISEASES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MONOSACCHARIDES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOISOTOPES; SACCHARIDES; SOMATIC CELLS; VERTEBRATES