Published April 1987 | Version v1
Journal article Metadata-only

Synthesis and organ distribution of 35S-thiophosphonic acid, a possible radiopharmaceutical for osseous metastases treatment

Creators

  • 1. Rostock Univ. (German Democratic Republic). Radiologische Klinik
  • 2. Akademie der Wissenschaften der DDR, Berlin. Zentralinstitut fuer Organische Chemie

Description

/sup 99m/Tc-labelled diphosphonic acids are used in routine diagnostics of skeletal diseases, with a high accumulation rate in areas of intensive bone metabolism. Therefore they seem to be well suited for treatment of malign osseous processes after incorporation of a low-energy β- emitter with its low bone marrow radiation dose. A synthesized 35S-thiophosphonic acid was tested in rats as /sup 99m/Tc complex and revealed an organ distribution pattern typical for diphosphonic acids. The 1 to 10 accumulation ratio of normal and damaged bone tissue, resp., renders the substance suitable for radiotherapy

Additional details

Additional titles

Original title (German)
S-Thiophosphonsaeure, ein moegliches Radiotherapeutikum bei der Behandlung von Knochenmetastasen - Synthese und Bioverteilung

Publishing Information

Journal Title
Isotopenpraxis
Journal Volume
23
Journal Issue
4
Series
Isotopenpraxis.
Journal Page Range
125-128
ISSN
0021-1915
CODEN
IPRXA

INIS

Country of Publication
Germany
Country of Input or Organization
German Democratic Republic
INIS RN
18056234
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
BONE MARROW; CHEMICAL PREPARATION; METASTASES; ORGANIC PHOSPHORUS COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RADIOTHERAPY; RATS; SKELETON; SULFUR 35; TECHNETIUM COMPLEXES; TECHNETIUM 99; TISSUE DISTRIBUTION
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COMPLEXES; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; DRUGS; EVEN-ODD NUCLEI; HEMATOPOIETIC SYSTEM; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SULFUR ISOTOPES; SYNTHESIS; TECHNETIUM ISOTOPES; THERAPY; TISSUES; TRANSITION ELEMENT COMPLEXES; VERTEBRATES; YEARS LIVING RADIOISOTOPES