Radiogenotoxicological effect of fission fragment 147Pm on BALB/C mice

The purpose of the present study is to ascertain the radiogenotoxicological effect, such as chromosome aberration, sister chromatid exchange and micronucleus formation in bone marrow cells induced by fission fragment 147Pm. 42 male BALB/C strain mice were used. Results indicated that the chromosome aberration rates were elevated along with increasing doses of 147Pm. It showed a linear relationship between dose and effect: Y = -4.403 + 1.435 Ln X. Five aberrations in one cell could be induced. This phenomenon might be partly due to nonuniform irradiation of bone marrow cells by local deposition of 147Pm. Chromatid type of chromosome aberrations could also be observed. Chromatid breakages were predominatnt, accompanied by a few chromosome fragments and translocations. The micronucleus rates were also elevated with the increase of contamination dose of 147Pm