Published 1996
| Version v1
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Radiolabelling of chelators for monoclonal antibodies
Creators
- 1. St. George Hospital Cancer Care Centre, Kogarah, NSW (Australia)
- 2. University of Technology, Sydney, NSW (Australia). Dept. of Chemistry
- 3. Sydney Univ., NSW (Australia). Dept. of Pharmacy
Description
Full text: Two radiolanthanides, namely Terbium-152 and Samarium-153, which are primarily beta-emitters, have been used to radiolabel bicyclic anhydride of DTPA. In this study, contrary to the conventional procedure, the chelator is radiolabelled first and then conjugated to melanoma antibody 7.2.29, with an attempt to achieve a better radioimmunoconjugate with less damage to immunoreactivity of the protein. These two radioimmunoconjugates were subjected to QC analyses. Their stability and biological effectiveness toward cancer cells were evaluated
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29003509.pdf
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Additional details
Publishing Information
- Imprint Place
- Lucas Heights (Australia)
- Imprint Title
- Radiation'96. Conference handbook
- Imprint Pagination
- 97 p.
- Journal Page Range
- p. 63.
- Report number
- INIS-AU--0006
Conference
- Title
- 18. AINSE radiation chemistry conference; 15. AINSE radiation biology conference; 3. national workshop on experimental radiation oncology.
- Acronym
- Radiation' 96
- Dates
- 10-12 Nov 1996.
- Place
- Lucas Heights (Australia).
INIS
- Country of Publication
- Australia
- Country of Input or Organization
- Australia
- INIS RN
- 29003509
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- DTPA; LABELLING; MONOCLONAL ANTIBODIES; QUALITY CONTROL; RADIOPHARMACEUTICALS; SAMARIUM 153; STABILITY; TERBIUM 152
- Descriptors DEC
- AMINO ACIDS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHELATING AGENTS; CONTROL; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RARE EARTH NUCLEI; RESPONSE MODIFYING FACTORS; SAMARIUM ISOTOPES; TERBIUM ISOTOPES