Toxicity of inhaled 144CeCl3 in Beagle dogs. XV

The metabolism, dosimetry and biological effects of inhaled 144CeCl3 in Beagle dogs are being studied to assess the consequences of inhaling 144Ce. Studies have shown that 144Ce deposited in lung as 144CeCl3 is translocated at a moderately rapid rate to liver and skeleton and that significant radiation doses are accumulated by all three organs. The dogs exposed to 144Ce had long-term retained burdens that ranged from 2.6 to 360 μCi 144Ce/kg body weight. All 55 of the dogs exposed to 144CeCl3 and 15 of 17 control dogs have died. There are two surviving control dogs