Published May 1992
| Version v1
Journal article
Synthesis of [3H]naltrindole
- 1. Searle (G.D.) and Co., Skokie, IL (United States). R and D Div.
Description
[3H]Naltrindole ([3H]1) was prepared for use as a selective radiolabeled ligand for delta opioid receptors. The Fischer indole synthesis from naltrexone and 2,4-dibromophenylhydrazine produced dibromide precursor 2, which was catalytically dehalogenated with carrier free tritium gas to afford [3H]1 in 45.8% yield at a specific activity of 39.5 Ci/mmol. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 31
- Journal Issue
- 5
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 375-380
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 23085572
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- INDOLES; LABELLED COMPOUNDS; LIGANDS; RECEPTORS; SYNTHESIS; TRITIUM
- Descriptors DEC
- AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRROLES; RADIOISOTOPES; YEARS LIVING RADIOISOTOPES