Initial experience with 99mTc-tetrofosmin scintimammography

Full text:99mTc-tetrofosmin prone scintimammography was performed in 12 patients with palpable breast lesions and abnormal mammography findings. Right and left lateral prone and anterior supine views were obtained starting at 10 min of intravenous injection of 20 mCi 99mTc labelled tetrofosmin. Focal increased concentration of radiopharmaceutical as compared to surrounding normal breast tissue was considered positive for malignant disease. Patients underwent surgery with histopathological examination. 7 of the eight malignant lesions showed accumulation of 99mTc-tetrofosmin. Involved lymph nodes were also seen to concentrate the radiopharmaceutical. Four benign breast masses did not show focal 99mTc-tetrofosmin uptake. Initial results suggest that 99mTc-tetrofosmin could play a useful role in evaluation of breast tumours