Dual pathway for gluconeogenesis from D-glycerate and L-glycerate
Description
In freshly isolated hepatocytes, the time course and substrate concentration dependences of glucose synthesis from D-glycerate are similar to those from L-glycerate even though the cellular content of D-glycerate was markedly less when L-glycerate was the substrate. Glucose synthesis from the isomers were differentially affected by various metabolic inhibitors. These differences cannot be fully explained by the relatively more sensitive nature of gluconeogenesis from L-glycerate to cytosolic NADH/NAD ratio. The results indicate that only a portion of the glucose formed from D- and L-glycerate involves the well-known pathway comprising lactate dehydrogenase, D-glycerate dehydrogenase and D-glycerate kinase for generation of 2-phospho-D-glycerate from D- and L-glycerate. Studies employing 14C formaldehyde indicate an additional pathway involving transketolase for gluconeogenesis from these substrates
Additional details
Publishing Information
- Journal Title
- Fed. Proc., Fed. Am. Soc. Exp. Biol.
- Journal Volume
- 46
- Journal Issue
- 6
- Journal Series
- Fed. Proc., Fed. Am. Soc. Exp. Biol.
- Journal Page Range
- 2010
- ISSN
- 0014-9446
- CODEN
- FEPRA
Conference
- Title
- 78. annual meeting of the American Society of Biological Chemists conference.
- Dates
- 7-11 Jun 1987.
- Place
- Philadelphia, PA (USA).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 19022151
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Conference
- Quality check status
- Yes
- Descriptors DEI
- BIOLOGICAL PATHWAYS; BIOSYNTHESIS; CARBON 14 COMPOUNDS; FORMALDEHYDE; GLUCOSE; LACTATE DEHYDROGENASE; LIVER CELLS; NAD; NADH2; PHOSPHOTRANSFERASES; TRACER TECHNIQUES;
- Descriptors DEC
- ALDEHYDES; ANIMAL CELLS; CARBOHYDRATES; CARBON COMPOUNDS; COENZYMES; DEHYDROGENASES; ENZYMES; HEXOSES; ISOTOPE APPLICATIONS; MONOSACCHARIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; OXIDOREDUCTASES; PHOSPHORUS-GROUP TRANSFERASES; SACCHARIDES; SOMATIC CELLS; SYNTHESIS; TRANSFERASES;
Optional Information
- Secondary number(s)
- CONF-870644--.