Published May 1, 1987 | Version v1
Journal article

Dual pathway for gluconeogenesis from D-glycerate and L-glycerate

  • 1. Univ. of Madison, WI

Description

In freshly isolated hepatocytes, the time course and substrate concentration dependences of glucose synthesis from D-glycerate are similar to those from L-glycerate even though the cellular content of D-glycerate was markedly less when L-glycerate was the substrate. Glucose synthesis from the isomers were differentially affected by various metabolic inhibitors. These differences cannot be fully explained by the relatively more sensitive nature of gluconeogenesis from L-glycerate to cytosolic NADH/NAD ratio. The results indicate that only a portion of the glucose formed from D- and L-glycerate involves the well-known pathway comprising lactate dehydrogenase, D-glycerate dehydrogenase and D-glycerate kinase for generation of 2-phospho-D-glycerate from D- and L-glycerate. Studies employing 14C formaldehyde indicate an additional pathway involving transketolase for gluconeogenesis from these substrates

Additional details

Publishing Information

Journal Title
Fed. Proc., Fed. Am. Soc. Exp. Biol.
Journal Volume
46
Journal Issue
6
Journal Series
Fed. Proc., Fed. Am. Soc. Exp. Biol.
Journal Page Range
2010
ISSN
0014-9446
CODEN
FEPRA

Conference

Title
78. annual meeting of the American Society of Biological Chemists conference.
Dates
7-11 Jun 1987.
Place
Philadelphia, PA (USA).

INIS

Optional Information

Secondary number(s)
CONF-870644--.