Published May 1982
| Version v1
Journal article
No-carrier-added synthesis of [1-11C] pyruvic acid
Creators
- 1. Washington Univ., St. Louis, MO (USA). Edward Mallinckrodt Inst. of Radiology
Description
Carbon-11 labeled pyruvic acid has been prepared in no-carrier added form by a new chemical synthesis based on the carboxylation of a masked acyl carbanion. The addition of 11CO2 to the lithium aldimine from methyllithium and 1,1,3,3-tetramethylbutylisocyanide yields the α-imino acid, which is then hydrolysed to the desired [1-11C]pyruvic acid. The synthesis yields 550-960 MBq of labeled pyruvic acid suitable for in vivo biological studies, with a total synthesis and purification time of 35-40 min. (author)
Additional details
Publishing Information
- Journal Title
- Int. J. Appl. Radiat. Isot.
- Journal Volume
- 33
- Journal Issue
- 5
- Series
- Int. J. Appl. Radiat. Isot.
- Journal Page Range
- 359-361
- ISSN
- 0020-708X
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 14716853
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBON 11; CARBOXYLATION; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; HYDROLYSIS; PURIFICATION; PYRUVIC ACID; RADIOPHARMACEUTICALS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; DECOMPOSITION; DRUGS; EVEN-ODD NUCLEI; ISOTOPES; KETO ACIDS; LABELLED COMPOUNDS; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SOLVOLYSIS; SYNTHESIS