Published February 2005 | Version v1
Journal article Metadata-only

Genomic instability induced by γ-ray irradiation analyzed by cytokinesis-block MN assay in CHL cell line

Creators

  • 1. Jilin Univ. Radiobiology Unit of Public Health School, Changchun (China)
  • 2. Center of Scientific Information of China Inst. for Radiation Protection, Taiyuan (China)

Description

To analyze the genomic instability induced by γ-rays, cytokinesis-block MN assay was employed to investigated the gene damage of cells and their progeny cells exposed to radiation. The micronucleus frequency were related to the irradiation dose and decreased as the culture time lengthened. There was a correlation between the micronucleus frequency and the initial dose after the second irradiation. The micronucleus frequency may be causally related to radiation-induced genomic instability which is expressed as chromosomal damage leading to micronuclei. (authors)

Additional details

Publishing Information

Journal Title
Journal of Radiation Research and Radiation Processing
Journal Volume
23
Journal Issue
1
Journal Page Range
p. 45-48
ISSN
1000-3436

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
37089537
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANIMAL CELLS; BENCH-SCALE EXPERIMENTS; BIOLOGICAL RADIATION EFFECTS; CHROMOSOMES; FIBROBLASTS; GENES; LYMPHOKINES; RADIATION INJURIES; RADIOSENSITIVITY; RATS
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CONNECTIVE TISSUE CELLS; DISEASES; GROWTH FACTORS; INJURIES; MAMMALS; MITOGENS; ORGANIC COMPOUNDS; PROTEINS; RADIATION EFFECTS; RODENTS; SENSITIVITY; SOMATIC CELLS; VERTEBRATES

Optional Information

Notes
5 figs., 9 refs.